Why have we developed our bio nanoparticle technology?

The biologics industry is expanding rapidly as the potential of biological therapies grows in recognition. The field is also expected to become more versatile as it grows from antibody-focused production to gene and cell therapies, exosomes, fusion proteins and nanotechnology approaches. However, despite their success so far, biologics come with a number of challenges.

Among these is that the production cost of biologics is high. Despite this, increased opportunities for patient centricity exist, including better formulations and different modes of administration to aid drug delivery. Direct nanoforming of biologics is a promising new approach to allow more life-changing large-molecule drugs to reach the market, which was a key driving force behind the development of our proprietary biological technology.

Creating new possibilities

By reducing the size of large-molecule drugs, our technique can improve existing drug delivery approaches and enable new drug delivery routes, as well as facilitating the creation of drugs with completely new properties.

This technique aims to open up new opportunities within drug delivery such as crossing the blood-brain barrier, subcutaneous, intranasal, transdermal and oral forms of biologics.

For example, tight junctions within the blood-brain barrier prevent the passage up to 98% of small molecules and almost all biologics. Through nanoforming, it may be possible to enable the transport of biologics to the brain through the intranasal drug delivery route. This could aid the development of therapies for neurodegenerative diseases.

Ultimately, we aim to initiate a new era of novel drug development and enable more patients around the world to benefit from next-generation drug therapies.

Our technology

Our biological nanoforming technology can deliver large-molecule drug particles as small as 50 nm while retaining biological activity. It’s effectiveness has been demonstrated on proteins in the 6 kDa – 140 kDa range, and it is capable of engineering particle sizes to specific requirements. Our advanced technology can be applied across the biologics field to potentially:

  • Change delivery routes
  • Increase uptake
  • Enable new drug combinations
  • Tailor release profiles
  • Enhance drug loading capacity in formulations
  • Implement lighter infrastructures for drug logistics