b'Small is green Our nanoforming services Our company roots are in the luscious Finnish countryside,provide solutions to complex and this is reflected in our commitment to sustainability. formulation challengesOur CESS nanoparticle engineering technology isa bottom-up recrystallization process utilizing supercritical carbon dioxide repurposed from industry waste as a solvent.Pharmacokinetic improvementsThe process can eliminate the need for excipients and hasLow drug compound solubility is a major cause of a small manufacturing footprint, while the use of a greenattrition in the pharmaceutical industry. Nanoforming solvent facilitates environmentally friendly scale up. increases the specific surface area of API particles, enabling significant improvements in dissolution rateand thus bioavailability. Increased bioavailability also means a lower dosage is required for a therapeutic effectAdditional drug delivery applicationsOur nanoparticles are being used in drug developments to improve brain penetration via intranasal administration. Nanoparticles can also be used for novel applicationsin ocular, pulmonary and transdermal drug delivery.Commercial opportunitiesOur particle engineering services can improve the performance of both NCEs and drugs currently on the market by enhancing formulations. The commercial opportunities of our work also include life cycle extension, additional patent protection and thecreation of barriers to generic competition.12 13'