b'Small MoleculeBenefits of CESS NanoparticlesWhat is CESS and how does it work?Our multi-patented Controlled Expansion of Supercritical Solutions (CESS)Controlled Controlled Controlledtechnology is a bottom-up recrystallization technique that enables the creation particle shape particle size polymorphismof API nanoparticles directly from solution. The technique works by controllingthe solubility of an API in supercritical carbon dioxide (scCO ) in a process that Our nanoforming process canOur technology can producePolymorphic purity tests have 2 control the shape of particles,nanoparticles as small as 10 nm.shown that stable single is free from excipients and organic solvents. CESS represents a significantleading to greater uniformity. Smaller particles have greater activepolymorphs can be produced improvement over previous supercritical technologies due to the employment surface areas, which permits anwith defined process parameters, of controlled mass transfer, flow and pressure reduction. increased rate of dissolution. enabling polymorphic control.Discover our innovativeuse of sparse-dataartificial intelligenceCESS 3Our STARMAP 2.0 platform utilizes sparse-data AI to enhance drug discovery and development by picking the Before nanoforming After nanoforming winners among candidate molecules that are predictedCESS 1 CESS 4____40m____ ____5m____ to be best amenable to CESS-powered nanoforming. The technology augments experimental results with detailed expert knowledge to allow sensible predictionsCESS 7to be made regarding drug development success. CESS 2 CESS 5CESS 68 9'