Atovaquone (Wellvone®, Mepron®), used to treat malaria, was successfully nanoformed. Precise control over process parameters enabled the separate production of three polymorphs, with Form III available in both rod-like or spherical nanocrystals, illustrating the tunability of both polymorphic form and morphology.
Due to the high pressure and temperature ranges explored using supercritical CO2 in Nanoforms CESS® process, there is a great opportunity to screen for novel polymorphs. Nanoform has created previously unknown polymorphs many times for our customers, creating new intellectual property and patent protection for their products.