small is powerful for small molecules
Our award-winning Controlled Expansion of Supercritical Solutions (CESS®) technology enables the creation of API nanoparticles directly from solution. The process can be applied to most small molecules, with a high success rate.
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How does CESS® work?
CESS® is a bottom-up method of recrystallization that works by controlling the solubility of an API in supercritical carbon dioxide (scCO₂), enabling crystallization at a range of temperatures and pressures. CESS® represents a significant improvement over previous supercritical technologies due to the employment of controlled mass transfer, flow and pressure reduction. The use of scCO₂ permits a green particle engineering process with pharmaceutical CO₂ that is free from excipients and organic solvents.
Benefits of CESS®
Controlled particle size
Particle size tunability tailors bioavailability profiles bringing novel opportunities for patient-centricity
Controlled particle morphology
Ability to manipulate particle morphology enables formulation flexibility
Polymorph selection and generation including identification of novel forms
Particle shape control
Control of morphology whilst maintaining the same polymorph
Particle size control
Particle size can be tailored depending on product performance requirements
Generation of specific polymorph possible independent of nanoparticle size
Get in touch to find out how our CESS® technology can help your small-molecule drugs reach their full therapeutic potential