Benefits of CESS®

Controlled
particle shape

Our nanoforming process can control the shape of particles, leading to greater uniformity.

Controlled
particle size

Our technology can produce nanoparticles as small as 10 nm. Smaller particles have greater active surface areas, which permits an increased rate of dissolution.

Controlled
polymorphism

Polymorphic purity tests have shown that stable single polymorphs can be produced with defined process parameters enabling polymorphic control.

How does CESS® work?

CESS® is a bottom-up method of recrystallization that works by controlling the solubility of an API in supercritical carbon dioxide (scCO2). The use of scCO2 permits a green particle engineering process with pharmaceutical CO2 that is free from excipients and organic solvents. CESS® represents a significant improvement over previous supercritical technologies due to the employment of controlled mass transfer, flow and pressure reduction.

Before Nanoforming

After Nanoforming

Before Nanoforming

After Nanoforming

  • Nanoform the stars that will shine the brightest with…